Dr. Tendai Gadzikwa
An ideal anticancer delivery system must address a number of issues. 1) Cancerous tissue must be specifically targeted. 2) Elimination by the immune system must be avoided. 3) Release of the anticancer agent must be controlled. 4) Drug resistance should be prevented. Metal-organic framework (MOF) nanocrystals can be synthesized such that they are composed of multiple drugs, bear multiple targeting and masking moieties, and have pores that encapsulate additional anticancer compounds. Our MOFs would deliver combination therapeutics with multiple release profiles, and would selectively target cancerous tissue and evade the immune response, all while containing metals for imaging.