Dr. Stella Lee
Our research focuses on protein transport in the cells in health and diseases. Currently, we are working on several proteins that are involved in a lysosomal storage disease, neuronal ceroid lipofuscinosis (NCL). Several lines of evidence suggest that specific forms of NCLs may be due to defects in mitophagy, an essential cellular process to bring damaged or unwanted mitochondria to lysosomes for degradation. Mitochondrion is the power house of the cell. Aberrant mitochondrial functions and metabolism have been linked to cancer cells. We use mammalian cell culture combining cell biological and biochemical approaches to understand the functions of these NCL proteins under normal condition, as well as their connections to mitochondria and the mitophagy process.