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Johnson Cancer Research Center

Cancer Research Collaboration of Excellence in Tumor Microenvironment

The Cancer Research Collaboration of Excellence (CRCE) in Tumor Microenvironment, established in May 2021, is a multidisciplinary team of researchers from five departments in four colleges of Kansas State University. 

Many conventional cancer therapies fail due to factors related to the tumor's environment, called the microenvironment. This CRCE, led by Brad Behnke, professor of kinesiology, will examine the tumor microenvironment changes that occur in response to low-dose radiation, such as DNA mutations. The collaboration aims to identify the changes and design methods of combatting them.

Investigations include:
  1. Does exercise increase oxygenation in breast tumors (which normally flourish in the absence of oxygen)?
  2. Does nitrate supplementation increase tumor oxygenation and decrease tumor growth?
  3. What are the vitamin D needs of ovarian tumors (considering vitamin D status seems to relate to tumor progression)?
  4. What DNA mutations occur in response to radiation?
Investigators:

Brad Behnke, Kinesiology, Principal Investigator

Amir Bahadori, Mechanical & Nuclear Engineering

Carl Ade, Kinesiology

David Poole, Anatomy & Physiology

Chieko Azuma, Radiation Oncology

Wei-Wen Hsu, Statistics